Screening 3D Brain Cell Cultures for Drug Discovery

3D brain cell culture models are reshaping how researchers study neurological disorders and evaluate new therapeutic candidates. Unlike traditional two-dimensional systems, organoids and spheroids offer a more realistic window into disease mechanisms and drug responses. As adoption grows, these models are quickly becoming essential tools for labs focused on translational neuroscience and high-throughput screening.

In a webinar hosted by The Scientist and sponsored by Aviva, Cathryn Haigh, PhD and Lena Smirnova, PhD share how cutting-edge 3D systems are driving new insights into complex neurobiology. Their work highlights the strengths of these models for building better assays and investigate complex neurobiological processes.

What You’ll Learn

• How prion-infected human cerebral organoids are being used to improve therapeutic development for prion diseases
• How applying brain microphysiological systems with translational potential enhance investigations into complex neurobiological processes, including metal-induced synaptic changes​​
• Why 3D systems offer a more accurate framework for investigating disease progression, neurotoxicity, and drug efficacy

Together, these talks illustrate a growing shift in neuroscience toward models that better mirror human biology and accelerate discovery.

Watch the full webinar on YouTube to explore the research in depth.

👉 Screening 3D Brain Cell Cultures for Drug Discovery