How Aviva’s Protein On Demand Service Gives You What You Need

When it comes to advancing your research, the last thing you want is to compromise on protein quality or availability. At Aviva, we understand that every experiment is different, and sometimes off-the-shelf just doesn’t cut it, while fully custom options can be cost prohibitive. That’s where our Protein On Demand (POD) service comes in!

Overall, we offer three flexible tiers of customization:

• Catalog Proteins: A wide selection of pre-validated proteins from common targets across species
• Made-to-Order Protein On Demand: You pick the tag, scale, and expression system — ideal for routine use with specific formats
• Fully Custom: From sequence to final QC, we’ll work with you to design, express, and purify exactly what your assay or study demands

You choose the tag, expression system, and scale. We handle the rest. Whether you're designing an assay, screening a target, or scaling for downstream applications, our team delivers high-purity proteins that match your research goals.

Expression Systems That Match Your Goals

Different projects call for different expression systems — and we’ve got options:

• E. coli: Fast, scalable, and ideal for high-yield expression when post-translational modifications (PTMs) aren’t required.

• Yeast (Pichia pastoris): Adds some glycosylation capacity for functional proteins, with strong yield and stability.

• Baculovirus (sf9 cells): Delivers high-level protein expression with limited but useful PTM options.

• Mammalian (HEK293 or CHO): When complex PTMs matter most, mammalian systems offer the best physiological relevance. HEK293 is our preferred host, but CHO is available upon request.

Every system is chosen based on your target’s characteristics and your end-use needs. If you're unsure what expression system is right for you, just ask and we’ll help you find the right fit.

Tag Options That Work for You

Tags are useful tools for purification, detection, and stability, and we support a wide range of commonly used N- and C-terminal tags, including:

• 6xHis, 10xHis
• GST, His-GST
• SUMO, His-SUMO
• Myc
• Tag-free (optional with additional processing and fee)

FYI - If your desired tag isn’t listed, let us know. We’ll do our best to accommodate and communicate if alternatives are needed. We have a high success rate when expressing alternative tags. 

Size, Format, and Delivery — Your Call

Some workflows need just enough protein to get started. Others need a scalable solution with batch consistency. We offer flexible sizing and can deliver proteins in lyophilized or liquid form. Short on time? Liquid formats can help you jump right into your work. Need stability? Lyophilized proteins offer a longer shelf life. Just let us know your preference when you order.

Semi-Custom: When Speed Meets Precision

Our catalog includes thousands of ready-to-ship proteins. But beyond that, millions of semi-custom targets are just a step away. These are made-to-order proteins not yet developed, but with high expression success rates (99.1%). While tag type is assigned during manufacturing, custom tag requests can be submitted and are fulfilled whenever feasible.

Speed, quality, and service that scientists trust

Every protein is produced using well established workflows and delivered with detailed documentation. If you have questions, our team is available to provide guidance on available formats and options.

Ready to get started?

Tell us what you need and we’ll get it in motion. Search your target here or submit your target and specs to techsupport@avivasysbio.com to explore POD options with our Tech Support Scientist.